SPRAVATO® is a prescription nasal spray designed to be used in combination with an oral antidepressant for adults struggling with treatment-resistant depression. It differs from traditional antidepressants by targeting the brain’s glutamate system—offering a new, fast-acting approach for those who haven’t experienced relief with two or more other medications. While most antidepressants can take weeks or even months to take effect, SPRAVATO® has been shown in clinical studies to provide noticeable symptom improvement within hours to days. For many, it represents a breakthrough option when other treatments have fallen short, opening the door to hope and healing.