Breakthrough Relief for Treatment-Resistant Depression:Discover SPRAVATO®

If you or a loved one is struggling with depression that hasn’t improved with traditional
antidepressants, you’re not alone. You may have more options than you think! SPRAVATO®
(esketamine) is a revolutionary FDA-approved treatment designed for adults facing
treatment-resistant depression (TRD).

What Is SPRAVATO®?
SPRAVATO® is a nasal spray medication used in combination with an oral antidepressant.
It’s not your typical antidepressant; in fact, it works differently from anything else currently
on the market. SPRAVATO® targets the brain’s glutamate system, offering a fast-acting
approach to managing depressive symptoms when other treatments haven’t worked.

Why Consider SPRAVATO®?
If you’ve tried two or more antidepressants without relief, SPRAVATO® may be a new path
forward. In clinical studies, patients reported noticeable improvement in their symptoms
within hours to days, compared to the weeks or months typical antidepressants often take.
What to Expect

SPRAVATO® is administered under the supervision of a healthcare provider in a certified
treatment center. This ensures your safety during the 2-hour observation period after each
dose. Treatment plans typically start with twice-weekly sessions, gradually tapering as
your symptoms improve.
Is SPRAVATO® Right for You?
SPRAVATO® is intended for adults with:

• Major depressive disorder who hasn’t responded to other antidepressants
• Suicidal thoughts in the context of depression (in some cases)
  Because this treatment isn’t right for everyone, especially those with certain medical
  histories, it’s essential to speak with a provider to see if SPRAVATO® is a safe, appropriate
  option for you.